Keeping innate immunity at bay

Keeping inflammation at bay

Cells dying by apoptosis can trigger an anti-inflammatory gene response in other cells by releasing a compound called adenosine monophosphate.

Immunology: Keeping mother at bay

Like its better-known polymorphic relatives, HLA-G, a relatively unpolymorphic class I MHC molecule expressed by fostal trophoblast cells, binds short peptides with a defined sequence motif; HLA-G may play an important role in maternal tolerance to a fostus.

Lupus nephritis: keeping the wolf at bay.

From the beginning part of this century, we have witnessed a dramatic improvement in the prognosis of patients with SLE. Several factors have contributed to this improvement, such as a better understanding of the pathophysiology, recognizing the essential role of the kidney biopsy in defining and prognosticating lupus nephritis (LN), and the development of relatively effective treatment for sev...

SNPing away at innate immunity.

(CF) is a genetic disorder caused by mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) (1). A hallmark of the disease is a defect in chloride con-ductance, particularly in serous gland cells and respiratory epithelial cells. Depletion of the periciliary liquid layer, partly due to a defect in ciliary transport, has pleiotropic consequences with respect to local host def...

Executive Noncompetes: Keeping Talent in House or At Bay?